Simulated moving bed chromatography separation system:
The simulated moving bed technology is developed from the real moving bed technology. The real moving bed technology appeared in the late 20s, the principle is to use the stationary phase to move in the direction opposite to the flow of the mobile phase at an appropriate rate during the separation process, so as to improve the separation efficiency and shorten the non-adsorption operation time , but there are problems such as difficult movement of the stationary phase and serious wear and tear, and finally the simulated moving bed technology was born. The simulated moving bed system connects multiple chromatographic columns in series, and uses valve switching technology to change the position of the inlet and outlet of the feed liquid, simulating the countercurrent continuous separation process of the real moving bed.
The simulated moving bed separation technology has the advantages of strong separation ability, easy to realize automatic control, especially beneficial to the separation of heat-sensitive and difficult-to-separate systems, and is suitable for continuous large-scale industrial production in preparative chromatography technology.
The simulated moving bed chromatographic separation system has been used in many production fields such as petroleum, fine chemical industry, biological fermentation, medicine, and food.